In Romans 16:20, Paul uses the specific imagery of Genesis 3:15 to describe what God is doing, right that moment, in and through His church. In 1 John 3:8, John speaks of Jesus as coming specifically to destroy the works of the devil. In Hebrews 2:14, the Scriptures speak of Jesus Christ as the destroyer of the devil himself. In Revelation 12, John uses the imagery of Genesis 3:15 to encapsulate and represent the entire progress of redemptive history. Repeatedly, the Scriptures evoke Genesis 3:15 to crystallize what God has been doing, and what He presently is doing, in His redemptive work.

STEPHEN G. MYERS, GOD TO US – COVENANT THEOLOGY IN SCRIPTURE, 162.